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l 203.99000 763.99000 204.21000 763.74000 204.64000 763.74000 c 205.08000 763.74000 l 205.08000 762.98000 l 204.39000 762.98000 l 203.51000 762.98000 203.06000 763.46000 203.06000 764.41000 c 203.06000 769.14000 l 208.34000 765.65000 m 208.34000 764.38000 208.87000 763.74000 209.93000 763.74000 c 210.99000 763.74000 211.52000 764.38000 211.52000 765.65000 c 211.52000 766.90000 210.99000 767.53000 209.93000 767.53000 c 208.87000 767.53000 208.34000 766.90000 208.34000 765.65000 c 207.40000 765.63000 m 207.40000 767.40000 208.24000 768.29000 209.93000 768.29000 c 211.61000 768.29000 212.45000 767.40000 212.45000 765.63000 c 212.45000 763.87000 211.61000 762.99000 209.93000 762.99000 c 208.32000 762.99000 207.47000 763.87000 207.40000 765.63000 c 215.03000 762.98000 m 215.03000 768.29000 l 215.82000 768.29000 l 215.82000 767.61000 l 216.29000 768.06000 216.78000 768.29000 217.30000 768.29000 c 217.30000 767.51000 l 216.80000 767.51000 216.35000 767.28000 215.96000 766.84000 c 215.96000 762.98000 l 215.03000 762.98000 l 219.37000 768.29000 m 220.38000 768.29000 l 221.88000 764.14000 l 223.43000 768.29000 l 224.42000 768.29000 l 222.22000 762.83000 l 221.83000 761.86000 221.25000 761.26000 220.46000 761.02000 c 220.10000 761.68000 l 220.70000 761.94000 221.13000 762.37000 221.40000 762.95000 c 219.37000 768.29000 l f Q q 1 0 0 1 0 0 cm BT /F1 12 Tf 14.40000 TL ET q q 1 0 0 1 303.30710 781.11810 cm q 0 0 0 rg BT 1 0 0 1 0 2 Tm 26.92450 0 Td /F2+0 12 Tf 14 TL (Zpr\200va o v\201sledku zkou\202ky \043188624) Tj T* -26.92450 0 Td ET Q Q q 1 0 0 1 303.30710 733.27560 cm q BT 1 0 0 1 0 30 Tm 26.91250 0 Td 14 TL 0 0 0 rg /F3+0 12 Tf 14 TL (Detekce mutace c\0561640T\076C genu RYR1) Tj T* -25.12800 0 Td (zp\200sobuj\201c\201 malign\201 hypertermii po expozici) Tj T* 13.88400 0 Td (vyvol\202vac\201ch l\202tek u) Tj (\203) Tj (r\200zn\204ch plemen ps\200) Tj T* -15.66850 0 Td ET Q Q 0.28347 w 0.40000 0.40000 0.40000 RG n 72 711.49610 m 523.27560 711.49610 l S 0.82745 0.82745 0.82745 rg /gRLs0 gs 0.28347 w 0 0 0 RG /gRLs1 gs n 72 447.46460 451.27560 27.33858 re B* q 1 0 0 1 77.66929 453.13390 cm q 0 0 0 rg /gRLs2 gs BT 1 0 0 1 0 4 Tm /F3+0 12 Tf 16 TL (V\204sledek\072 Mutace nebyla detekov\202na \050N\057N\051) Tj T* ET Q Q q 1 0 0 1 72 695.24410 cm q BT 1 0 0 1 0 2 Tm 12 TL 0 0 0 rg /gRLs2 gs /F2+0 10 Tf 12 TL (Z\200kazn\203k) Tj /F3+0 10 Tf 12 TL (\072 Lucie Glaserov\202\054 Doubek 109\054 25101 Doubek\054 Czech Republic) Tj T* ET Q Q q 1 0 0 1 72 647.24410 cm q BT 1 0 0 1 0 38 Tm 12 TL 0 0 0 rg /gRLs2 gs /F2+0 10 Tf 12 TL (Vy\202et\204ovan\201\072) Tj T* /F3+0 10 Tf 12 TL (Vzorek\072 21\05527144) Tj T* (Datum p\205ijet\201 vzorku\072 06\05610\0562021) Tj T* (Vy\206et\205ovan\204 materi\202l\072 krev) Tj T* ET Q Q 0.84766 0.91016 0.71875 rg /gRLs2 gs 0.84766 0.91016 0.71875 RG /gRLs3 gs n 0 520.72440 63.49606 116.03150 re B* q 1 0 0 1 72 518.74020 cm q BT 1 0 0 1 0 112 Tm 12 TL 0 0 0 rg /F3+0 8 Tf 12 TL (\207daje poskytnut\210 z\202kazn\201kem) Tj T* /F2+0 10 Tf 12 TL (Jm\205no\072 Bezinka z Modr\205ho kr\200lovstv\203) Tj T* /F2+0 10 Tf 12 TL (Rasa\072 Kolie kr\200tkosrst\200) Tj T* /F3+0 10 Tf 12 TL (Mikro\211ip\072 900 085 001 081 321) Tj T* (Registra\211n\201 \211\201slo\072 CMKU\057CK\0571647\05720) Tj T* (Datum narozen\201\072 2\0563\0562020) Tj T* (Pohlav\201\072 samice) Tj T* (Datum odb\212ru\072 04\05610\0562021) Tj T* (P\205i odb\212ru byla ov\212\205ena identita jedince\056) Tj T* (Ov\212\205il\057a MVDr\056 Michaela Oravsk\202\054 KVL 5097) Tj T* ET Q Q n 0 520.72440 m 63.49606 520.72440 l S n 0 636.75590 m 63.49606 636.75590 l S q 99.21260 0 0 93.48031 409.88980 110.55120 cm /FormXob.04e955888da9f6c96f989cbcd979d7d9 Do Q 0 0 0 rg q 1 0 0 1 64.91339 79.37008 cm q BT 1 0 0 1 0 14 Tm 12 TL 0 0 0 rg /F3+0 10 Tf 12 TL (Genomia s\056r\056o\054 Republik\202nsk\202 6\054 31200 Plze\213\054 Czech Republic) Tj T* (www\056genomia\056cz\054 laborator\100genomia\056cz\054 tel\072 \053420 373 749 999) Tj T* ET Q Q BT 1 0 0 1 64.91339 59.52756 Tm /F3+0 6.70000 Tf 8.04000 TL (K\214d pro ov\212\205en\201 zpr\202vy je 68TX\0554ERR\0552HFX\055H979\055EHF5\056 Jd\212te na www\056genomia\056cz pro ov\212\205en\201\056) Tj T* ET BT 1 0 0 1 64.91339 51.02362 Tm /F3+0 6.70000 Tf 8.04000 TL (Zpr\202va o v\204sledku zkou\206ky nesm\201 b\204t bez souhlasu laborato\205e reprodukov\202na jinak ne\215 cel\202\056) Tj T* ET BT 1 0 0 1 64.91339 42.51969 Tm /F3+0 6.70000 Tf 8.04000 TL (V\204sledek se vztahuje pouze ke vzorku tak jak byl p\205ijat\056 Genomia neodpov\201d\202 za spr\202vnost \216daj\200 poskytnut\204ch z\202kazn\201kem\056) Tj T* ET BT 1 0 0 1 518.34910 42.51969 Tm /F3+0 6.70000 Tf 8.04000 TL (1 \057 1) Tj T* ET Q q 1 0 0 1 70.91339 566.59840 cm Q q 1 0 0 1 70.91339 450.94490 cm Q q 1 0 0 1 70.91339 442.44090 cm Q q 1 0 0 1 70.91339 435.24090 cm Q q 1 0 0 1 70.91339 423.24090 cm q 0 0 0 rg BT 1 0 0 1 0 2 Tm /F2+0 10 Tf 12 TL (Koment\200\204 k v\201sledku) Tj T* ET Q Q q 1 0 0 1 70.91339 416.04090 cm Q q 1 0 0 1 70.91339 356.04090 cm q BT 1 0 0 1 0 50 Tm -0.01394 Tw 12 TL 0 0 0 rg /F3+0 10 Tf 12 TL (Byla vy\206et\205ena p\205\201tomnost \211i absence mutace c\0561640T) Tj (\076) Tj (C genu RYR1 zp\200sobuj\201c\201 malign\201 hypertermie \050MH\051 po) Tj T* 0 Tw 1.39837 Tw (expozici vyvol\202vac\201ch l\202tek\056 MH p\205edstavuje z\202va\215nou komplikaci p\205i celkov\210 anestezii\054 kter\202 m\200\215e b\204t a\215) Tj T* 0 Tw 1.48683 Tw (fat\202ln\201\056 MH je farmakogenetick\202 choroba kostern\201ho svalstva\054 p\205i kter\210 doch\202z\201 k\203hyperkapii\054 tachykardii a) Tj T* 0 Tw 1.34706 Tw (hypertermii\054 kter\210 jsou vyvol\202ny reakc\201 na chemick\210 spou\206t\212\211e \055 v\203tomto p\205\201pad\212 anestetika\056 Posti\215en\201 psi) Tj T* 0 Tw (nemaj\201 \215\202dn\210 klinick\210 p\205\201znaky\054 dokud nejsou vystaveni vyvol\202vac\201m l\202tk\202m\056) Tj T* ET Q Q q 1 0 0 1 70.91339 348.84090 cm Q q 1 0 0 1 70.91339 288.84090 cm q 0 0 0 rg BT 1 0 0 1 0 50 Tm 3.55262 Tw /F3+0 10 Tf 12 TL (Mutace zp\200sobuj\201c\201 MH je d\212d\212na autosom\202ln\212 dominantn\212\056 Pouze jedin\202 kopie mutovan\210ho genu) Tj T* 0 Tw 2.31277 Tw (\050v\204sledek N\057P \050negativn\201 \057 pozitivn\201\051\051 nebo P\057P \050pozitivn\201 \057 pozitivn\201\051\051 je dosta\211uj\201c\201 pro vznik klinick\204ch) Tj T* 0 Tw 1.56134 Tw (p\205\201znak\200\056 Vzhledem k\203tomu\054 \215e posti\215en\201 jedinci jsou bez pod\202n\201 vyvol\202vaj\201c\201ch l\202tek zcela bez klinick\204ch) Tj T* 0 Tw 2.63277 Tw (p\205\201znak\200\054 mohou n\212kte\205\201 jedinci pro\215\201t cel\204 \215ivot\054 ani\215 by byla b\212hem \215ivota stanovena diagn\214za MH\056) Tj T* 0 Tw (V\203p\205\201pad\212 posti\215en\210ho jedince je riziko p\205enosu posti\215en\201 na potomka 50\045\056) Tj T* ET Q Q q 1 0 0 1 70.91339 281.64090 cm Q q 1 0 0 1 70.91339 269.64090 cm q 0 0 0 rg BT 1 0 0 1 0 2 Tm /F3+0 10 Tf 12 TL (Metoda\072 SOP172\055MH\054 p\205\201m\210 sekvenov\202n\201 DNA) Tj T* ET Q Q q 1 0 0 1 70.91339 262.44090 cm Q q 1 0 0 1 70.91339 226.44090 cm q BT 1 0 0 1 0 26 Tm 12 TL 0 0 0 rg /F3+0 10 Tf 12 TL (Datum vystaven\201 zpr\202vy\072 15\05610\0562021) Tj T* (Datum proveden\201 zkou\206ky\072 06\05610\0562021 \055 15\05610\0562021) Tj T* (Schv\202lila\072 Mgr\056 Martina \217afrov\202\054 vedouc\201 laborato\205e) Tj T* ET Q Q Q endstream endobj 6 0 obj << /Filter [ /ASCII85Decode /FlateDecode ] /BitsPerComponent 8 /Height 424 /Length 56430 /ColorSpace /DeviceRGB /Width 450 /Type /XObject /Subtype /Image >> stream Gb"-6m8'6bIQd[[jK52*iOg=RdEgGXD&8@OYd<_Kdr^55.ZhmWNiLZj@]d+f'3j3>`%P./f
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